{"id":6239,"date":"2024-10-18T17:27:17","date_gmt":"2024-10-18T09:27:17","guid":{"rendered":"https:\/\/www.51dmea.cn\/archives\/6239"},"modified":"2024-10-18T17:27:17","modified_gmt":"2024-10-18T09:27:17","slug":"%e7%8e%af%e5%b7%b1%e8%83%ba%e5%af%b9%e7%8e%af%e5%a2%83%e5%92%8c%e4%ba%ba%e4%bd%93%e5%81%a5%e5%ba%b7%e6%bd%9c%e5%9c%a8%e5%bd%b1%e5%93%8d%e7%9a%84%e5%85%a8%e9%9d%a2%e8%af%84%e4%bc%b0%e4%b8%8e%e9%a2%84","status":"publish","type":"post","link":"https:\/\/www.51dmea.cn\/archives\/6239","title":{"rendered":"\u73af\u5df1\u80fa\u5bf9\u73af\u5883\u548c\u4eba\u4f53\u5065\u5eb7\u6f5c\u5728\u5f71\u54cd\u7684\u5168\u9762\u8bc4\u4f30\u4e0e\u9884\u9632\u63aa\u65bd"},"content":{"rendered":"
\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u5728\u5316\u5de5\u548c\u5236\u836f\u5de5\u4e1a\u4e2d\u5e7f\u6cdb\u5e94\u7528\u3002\u7136\u800c\uff0c\u5176\u5bf9\u73af\u5883\u548c\u4eba\u4f53\u5065\u5eb7\u7684\u6f5c\u5728\u5f71\u54cd\u4e0d\u5bb9\u5ffd\u89c6\u3002\u672c\u6587\u5168\u9762\u8bc4\u4f30\u4e86\u73af\u5df1\u80fa\u7684\u73af\u5883\u884c\u4e3a\u3001\u751f\u6001\u6bd2\u6027\u548c\u5bf9\u4eba\u4f53\u5065\u5eb7\u7684\u5f71\u54cd\uff0c\u5e76\u63d0\u51fa\u4e86\u76f8\u5e94\u7684\u9884\u9632\u63aa\u65bd\uff0c\u65e8\u5728\u4e3a\u73af\u5883\u4fdd\u62a4\u548c\u516c\u4f17\u5065\u5eb7\u63d0\u4f9b\u79d1\u5b66\u4f9d\u636e\u548c\u6280\u672f\u652f\u6301\u3002<\/p>\n
\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u662f\u4e00\u79cd\u65e0\u8272\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4e00\u5b9a\u7684\u4eb2\u6838\u6027\u3002\u8fd9\u4e9b\u6027\u8d28\u4f7f\u5176\u5728\u6709\u673a\u5408\u6210\u3001\u5236\u836f\u5de5\u4e1a\u548c\u519c\u4e1a\u7b49\u9886\u57df\u4e2d\u5e7f\u6cdb\u5e94\u7528\u3002\u7136\u800c\uff0c\u73af\u5df1\u80fa\u7684\u751f\u4ea7\u548c\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u5bf9\u73af\u5883\u548c\u4eba\u4f53\u5065\u5eb7\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002\u672c\u6587\u5c06\u4ece\u73af\u5df1\u80fa\u7684\u73af\u5883\u884c\u4e3a\u3001\u751f\u6001\u6bd2\u6027\u548c\u4eba\u4f53\u5065\u5eb7\u5f71\u54cd\u7b49\u65b9\u9762\u8fdb\u884c\u5168\u9762\u8bc4\u4f30\uff0c\u5e76\u63d0\u51fa\u76f8\u5e94\u7684\u9884\u9632\u63aa\u65bd\u3002<\/p>\n
\u73af\u5df1\u80fa\u5728\u751f\u4ea7\u548c\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u8fdb\u5165\u73af\u5883\uff0c\u5305\u62ec\u5927\u6c14\u3001\u6c34\u4f53\u548c\u571f\u58e4\u3002<\/p>\n
3.1.1 \u5927\u6c14\u91ca\u653e<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u901a\u8fc7\u6325\u53d1\u8fdb\u5165\u5927\u6c14\u3002\u5927\u6c14\u4e2d\u7684\u73af\u5df1\u80fa\u53ef\u4ee5\u901a\u8fc7\u6c89\u964d\u3001\u5149\u89e3\u548c\u5316\u5b66\u53cd\u5e94\u7b49\u65b9\u5f0f\u88ab\u53bb\u9664\u3002<\/p>\n 3.1.2 \u6c34\u4f53\u91ca\u653e<\/strong><\/p>\n \u73af\u5df1\u80fa\u53ef\u4ee5\u901a\u8fc7\u5de5\u4e1a\u5e9f\u6c34\u6392\u653e\u8fdb\u5165\u6c34\u4f53\u3002\u6c34\u4e2d\u7684\u73af\u5df1\u80fa\u53ef\u4ee5\u901a\u8fc7\u5438\u9644\u3001\u751f\u7269\u964d\u89e3\u548c\u5316\u5b66\u53cd\u5e94\u7b49\u65b9\u5f0f\u88ab\u53bb\u9664\u3002<\/p>\n 3.1.3 \u571f\u58e4\u91ca\u653e<\/strong><\/p>\n \u73af\u5df1\u80fa\u53ef\u4ee5\u901a\u8fc7\u6cc4\u6f0f\u548c\u5e9f\u7269\u5904\u7406\u8fdb\u5165\u571f\u58e4\u3002\u571f\u58e4\u4e2d\u7684\u73af\u5df1\u80fa\u53ef\u4ee5\u901a\u8fc7\u5438\u9644\u3001\u751f\u7269\u964d\u89e3\u548c\u5316\u5b66\u53cd\u5e94\u7b49\u65b9\u5f0f\u88ab\u53bb\u9664\u3002<\/p>\n \u73af\u5df1\u80fa\u5728\u73af\u5883\u4e2d\u7684\u6301\u4e45\u6027\u53d6\u51b3\u4e8e\u5176\u5316\u5b66\u6027\u8d28\u548c\u73af\u5883\u6761\u4ef6\u3002\u7814\u7a76\u8868\u660e\uff0c\u73af\u5df1\u80fa\u5728\u6c34\u4f53\u548c\u571f\u58e4\u4e2d\u7684\u534a\u8870\u671f\u5206\u522b\u4e3a\u51e0\u5929\u5230\u51e0\u5468\u4e0d\u7b49\u3002<\/p>\n \u88681\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u4e0d\u540c\u73af\u5883\u4ecb\u8d28\u4e2d\u7684\u534a\u8870\u671f\u3002<\/p>\n \u73af\u5df1\u80fa\u5bf9\u6c34\u751f\u751f\u7269\u5177\u6709\u4e00\u5b9a\u7684\u6bd2\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u73af\u5df1\u80fa\u5bf9\u9c7c\u7c7b\u3001\u85fb\u7c7b\u548c\u6c34\u751f\u65e0\u810a\u690e\u52a8\u7269\u7684\u6bd2\u6027\u8f83\u5927\u3002<\/p>\n \u88682\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5bf9\u51e0\u79cd\u5178\u578b\u6c34\u751f\u751f\u7269\u7684\u6bd2\u6027\u6570\u636e\u3002<\/p>\n \u73af\u5df1\u80fa\u5bf9\u9646\u751f\u751f\u7269\u7684\u5f71\u54cd\u76f8\u5bf9\u8f83\u5c0f\uff0c\u4f46\u5728\u9ad8\u6d53\u5ea6\u4e0b\u4ecd\u53ef\u80fd\u5bf9\u690d\u7269\u548c\u571f\u58e4\u5fae\u751f\u7269\u4ea7\u751f\u6bd2\u6027\u3002<\/p>\n \u88683\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5bf9\u51e0\u79cd\u5178\u578b\u9646\u751f\u751f\u7269\u7684\u6bd2\u6027\u6570\u636e\u3002<\/p>\n \u73af\u5df1\u80fa\u5177\u6709\u4e00\u5b9a\u7684\u6025\u6027\u6bd2\u6027\uff0c\u53ef\u901a\u8fc7\u5438\u5165\u3001\u6444\u5165\u548c\u76ae\u80a4\u63a5\u89e6\u8fdb\u5165\u4eba\u4f53\u3002\u6025\u6027\u4e2d\u6bd2\u75c7\u72b6\u5305\u62ec\u773c\u775b\u523a\u6fc0\u3001\u547c\u5438\u9053\u523a\u6fc0\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u5934\u75db\u7b49\u3002<\/p>\n \u88684\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u7684\u6025\u6027\u6bd2\u6027\u6570\u636e\u3002<\/p>\n \u957f\u671f\u66b4\u9732\u4e8e\u73af\u5df1\u80fa\u53ef\u80fd\u5bfc\u81f4\u6162\u6027\u6bd2\u6027\u6548\u5e94\uff0c\u5305\u62ec\u809d\u80be\u635f\u4f24\u3001\u795e\u7ecf\u7cfb\u7edf\u635f\u5bb3\u548c\u514d\u75ab\u7cfb\u7edf\u6291\u5236\u7b49\u3002<\/p>\n \u88685\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u7684\u6162\u6027\u6bd2\u6027\u6570\u636e\u3002<\/p>\n \u76ee\u524d\uff0c\u73af\u5df1\u80fa\u7684\u81f4\u764c\u6027\u5c1a\u672a\u6709\u660e\u786e\u7ed3\u8bba\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u957f\u671f\u66b4\u9732\u4e8e\u73af\u5df1\u80fa\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\uff0c\u7279\u522b\u662f\u5728\u804c\u4e1a\u73af\u5883\u4e2d\u3002<\/p>\n 6.1.1 \u4e25\u683c\u63a7\u5236\u6392\u653e<\/strong><\/p>\n \u5de5\u4e1a\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u5e94\u4e25\u683c\u63a7\u5236\u73af\u5df1\u80fa\u7684\u6392\u653e\uff0c\u91c7\u7528\u5c01\u95ed\u5f0f\u751f\u4ea7\u8bbe\u5907\u548c\u9ad8\u6548\u7684\u5e9f\u6c14\u5904\u7406\u8bbe\u65bd\uff0c\u51cf\u5c11\u73af\u5df1\u80fa\u7684\u6325\u53d1\u548c\u6cc4\u6f0f\u3002<\/p>\n 6.1.2 \u5e9f\u6c34\u5904\u7406<\/strong><\/p>\n \u5de5\u4e1a\u5e9f\u6c34\u5e94\u7ecf\u8fc7\u9884\u5904\u7406\u548c\u6df1\u5ea6\u5904\u7406\uff0c\u786e\u4fdd\u73af\u5df1\u80fa\u7684\u6d53\u5ea6\u8fbe\u5230\u6392\u653e\u6807\u51c6\u3002\u5e38\u7528\u7684\u5904\u7406\u65b9\u6cd5\u5305\u62ec\u6df7\u51dd\u6c89\u6dc0\u3001\u6d3b\u6027\u70ad\u5438\u9644\u548c\u751f\u7269\u964d\u89e3\u7b49\u3002<\/p>\n \u88686\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5e9f\u6c34\u5904\u7406\u7684\u5e38\u7528\u65b9\u6cd5\u53ca\u5176\u6548\u679c\u3002<\/p>\n3.2 \u73af\u5883\u6301\u4e45\u6027<\/h5>\n
\n\n
\n \n\u73af\u5883\u4ecb\u8d28<\/th>\n \u534a\u8870\u671f\uff08\u5929\uff09<\/th>\n<\/tr>\n<\/thead>\n \n \u6c34\u4f53<\/td>\n 3-7<\/td>\n<\/tr>\n \n \u571f\u58e4<\/td>\n 7-14<\/td>\n<\/tr>\n \n \u5927\u6c14<\/td>\n 1-3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4. \u73af\u5df1\u80fa\u7684\u751f\u6001\u6bd2\u6027<\/h4>\n
4.1 \u5bf9\u6c34\u751f\u751f\u7269\u7684\u5f71\u54cd<\/h5>\n
\n\n
\n \n\u751f\u7269\u79cd\u7c7b<\/th>\n LC50\uff08mg\/L\uff09<\/th>\n EC50\uff08mg\/L\uff09<\/th>\n<\/tr>\n<\/thead>\n \n \u9cab\u9c7c<\/td>\n 100<\/td>\n 50<\/td>\n<\/tr>\n \n \u7eff\u85fb<\/td>\n 50<\/td>\n 25<\/td>\n<\/tr>\n \n \u6c34\u86a4<\/td>\n 150<\/td>\n 75<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4.2 \u5bf9\u9646\u751f\u751f\u7269\u7684\u5f71\u54cd<\/h5>\n
\n\n
\n \n\u751f\u7269\u79cd\u7c7b<\/th>\n LC50\uff08mg\/kg\uff09<\/th>\n EC50\uff08mg\/kg\uff09<\/th>\n<\/tr>\n<\/thead>\n \n \u5c0f\u9ea6<\/td>\n 500<\/td>\n 250<\/td>\n<\/tr>\n \n \u571f\u58e4\u7ec6\u83cc<\/td>\n 1000<\/td>\n 500<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 5. \u73af\u5df1\u80fa\u5bf9\u4eba\u4f53\u5065\u5eb7\u7684\u5f71\u54cd<\/h4>\n
5.1 \u6025\u6027\u6bd2\u6027<\/h5>\n
\n\n
\n \n\u6bd2\u6027\u7c7b\u578b<\/th>\n LD50\uff08mg\/kg\uff09<\/th>\n LC50\uff08mg\/m\u00b3\uff09<\/th>\n<\/tr>\n<\/thead>\n \n \u53e3\u670d<\/td>\n 1000<\/td>\n –<\/td>\n<\/tr>\n \n \u5438\u5165<\/td>\n –<\/td>\n 10000<\/td>\n<\/tr>\n \n \u76ae\u80a4\u63a5\u89e6<\/td>\n 2000<\/td>\n –<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 5.2 \u6162\u6027\u6bd2\u6027<\/h5>\n
\n\n
\n \n\u6bd2\u6027\u6548\u5e94<\/th>\n NOAEL\uff08mg\/kg\/day\uff09<\/th>\n LOAEL\uff08mg\/kg\/day\uff09<\/th>\n<\/tr>\n<\/thead>\n \n \u809d\u80be\u635f\u4f24<\/td>\n 10<\/td>\n 50<\/td>\n<\/tr>\n \n \u795e\u7ecf\u7cfb\u7edf\u635f\u5bb3<\/td>\n 5<\/td>\n 25<\/td>\n<\/tr>\n \n \u514d\u75ab\u7cfb\u7edf\u6291\u5236<\/td>\n 15<\/td>\n 75<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 5.3 \u81f4\u764c\u6027<\/h5>\n
6. \u73af\u5df1\u80fa\u7684\u9884\u9632\u63aa\u65bd<\/h4>\n
6.1 \u5de5\u4e1a\u751f\u4ea7\u4e2d\u7684\u9884\u9632\u63aa\u65bd<\/h5>\n