{"id":6240,"date":"2024-10-18T17:30:17","date_gmt":"2024-10-18T09:30:17","guid":{"rendered":"https:\/\/www.51dmea.cn\/archives\/6240"},"modified":"2024-10-18T17:30:17","modified_gmt":"2024-10-18T09:30:17","slug":"%e7%8e%af%e5%b7%b1%e8%83%ba%e4%bd%9c%e4%b8%ba%e4%b8%ad%e9%97%b4%e4%bd%93%e5%9c%a8%e5%88%b6%e8%8d%af%e5%b7%a5%e4%b8%9a%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%e7%8e%b0%e7%8a%b6%e4%b8%8e%e5%8f%91%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.51dmea.cn\/archives\/6240","title":{"rendered":"\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\u4e0e\u53d1\u5c55\u524d\u666f"},"content":{"rendered":"
\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u6709\u673a\u4e2d\u95f4\u4f53\uff0c\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u73af\u5df1\u80fa\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u5305\u62ec\u5176\u5728\u6297\u751f\u7d20\u3001\u6297\u75c5\u6bd2\u836f\u7269\u3001\u6297\u764c\u836f\u7269\u548c\u5176\u4ed6\u836f\u7269\u4e2d\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u5206\u6790\u73af\u5df1\u80fa\u5728\u4e0d\u540c\u836f\u7269\u5408\u6210\u4e2d\u7684\u5177\u4f53\u5e94\u7528\u6848\u4f8b\uff0c\u63a2\u8ba8\u4e86\u5176\u5728\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3001\u964d\u4f4e\u6210\u672c\u548c\u6539\u5584\u836f\u7269\u6027\u80fd\u65b9\u9762\u7684\u4f18\u52bf\u3002last\uff0c\u5c55\u671b\u4e86\u73af\u5df1\u80fa\u5728\u672a\u6765\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u53d1\u5c55\u524d\u666f\u3002<\/p>\n
\u73af\u5df1\u80fa\uff08Cyclohexylamine, CHA\uff09\u662f\u4e00\u79cd\u65e0\u8272\u6db2\u4f53\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u78b1\u6027\u548c\u4e00\u5b9a\u7684\u4eb2\u6838\u6027\u3002\u8fd9\u4e9b\u6027\u8d28\u4f7f\u5176\u5728\u6709\u673a\u5408\u6210\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u50ac\u5316\u6d3b\u6027\u548c\u4e2d\u95f4\u4f53\u529f\u80fd\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5236\u836f\u5de5\u4e1a\u7684\u53d1\u5c55\uff0c\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\u3002\u672c\u6587\u5c06\u7cfb\u7edf\u5730\u56de\u987e\u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u5e94\u7528\u73b0\u72b6\uff0c\u5e76\u63a2\u8ba8\u5176\u672a\u6765\u7684\u53d1\u5c55\u524d\u666f\u3002<\/p>\n
\u73af\u5df1\u80fa\u5728\u6297\u751f\u7d20\u7684\u5408\u6210\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u5934\u5b62\u83cc\u7d20\u7c7b\u6297\u751f\u7d20\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u5e38\u7528\u4e8e\u5236\u5907\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n
3.1.1 \u5934\u5b62\u83cc\u7d20\u7684\u5408\u6210<\/strong><\/p>\n \u88681\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5934\u5b62\u83cc\u7d20\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n 3.1.2 \u9752\u9709\u7d20\u7684\u5408\u6210<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u9752\u9709\u7d20\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e7f\u6cdb\u5e94\u7528\u3002\u901a\u8fc7\u4e0e\u53cd\u5e94\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u751f\u6210\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n \u88682\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u9752\u9709\u7d20\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n \u73af\u5df1\u80fa\u5728\u6297\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u5728\u6297HIV\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u9009\u62e9\u6027\u3002<\/p>\n 3.2.1 \u6297HIV\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n \u88683\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u6297HIV\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n 3.2.2 \u6297\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u6297\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u5728\u5965\u53f8\u4ed6\u97e6\uff08Oseltamivir\uff09\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n \u88684\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5965\u53f8\u4ed6\u97e6\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n \u73af\u5df1\u80fa\u5728\u6297\u764c\u836f\u7269\u7684\u5408\u6210\u4e2d\u4e5f\u8868\u73b0\u51fa\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u7d2b\u6749\u9187\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n 3.3.1 \u7d2b\u6749\u9187\u7684\u5408\u6210<\/strong><\/p>\n \u88685\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u7d2b\u6749\u9187\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n 3.3.2 \u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u5408\u6210<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08Pembrolizumab\uff09\u7684\u5408\u6210\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u901a\u8fc7\u4e0e\u6c28\u57fa\u9178\u884d\u751f\u7269\u53cd\u5e94\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u751f\u6210\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3002<\/p>\n \u88686\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5e15\u535a\u5229\u73e0\u5355\u6297\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n \u9664\u4e86\u4e0a\u8ff0\u836f\u7269\uff0c\u73af\u5df1\u80fa\u8fd8\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u836f\u7269\u5408\u6210\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5728\u9547\u75db\u836f\u3001\u5fc3\u8840\u7ba1\u836f\u7269\u548c\u6297\u708e\u836f\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u9009\u62e9\u6027\u3002<\/p>\n 3.4.1 \u9547\u75db\u836f\u7684\u5408\u6210<\/strong><\/p>\n \u88687\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u9547\u75db\u836f\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n 3.4.2 \u5fc3\u8840\u7ba1\u836f\u7269\u7684\u5408\u6210<\/strong><\/p>\n \u88688\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u5fc3\u8840\u7ba1\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n 3.4.3 \u6297\u708e\u836f\u7684\u5408\u6210<\/strong><\/p>\n \u88689\u5c55\u793a\u4e86\u73af\u5df1\u80fa\u5728\u6297\u708e\u836f\u5408\u6210\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n \u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u836f\u7269\u5408\u6210\u7684\u6548\u7387\u3002\u901a\u8fc7\u5f62\u6210\u7a33\u5b9a\u7684\u4e2d\u95f4\u4f53\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u964d\u4f4e\u53cd\u5e94\u7684\u6d3b\u5316\u80fd\uff0c\u52a0\u901f\u53cd\u5e94\u901f\u7387\uff0c\u4ece\u800c\u7f29\u77ed\u5408\u6210\u65f6\u95f4\uff0c\u63d0\u9ad8\u4ea7\u7387\u3002<\/p>\n 4.1.1 \u964d\u4f4e\u53cd\u5e94\u6d3b\u5316\u80fd<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u5f3a\u78b1\u6027\u548c\u4eb2\u6838\u6027\u4f7f\u5176\u80fd\u591f\u5728\u591a\u79cd\u53cd\u5e94\u4e2d\u5145\u5f53\u50ac\u5316\u5242\uff0c\u964d\u4f4e\u53cd\u5e94\u7684\u6d3b\u5316\u80fd\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u52a0\u901f\u7fa7\u9178\u4e0e\u9187\u7684\u53cd\u5e94\uff0c\u63d0\u9ad8\u4ea7\u7387\u3002<\/p>\n 4.1.2 \u52a0\u901f\u53cd\u5e94\u901f\u7387<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u5b58\u5728\u53ef\u4ee5\u663e\u8457\u52a0\u901f\u53cd\u5e94\u901f\u7387\u3002\u4f8b\u5982\uff0c\u5728\u9170\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4fc3\u8fdb\u9170\u6c2f\u4e0e\u9187\u7684\u53cd\u5e94\uff0c\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\u3002<\/p>\n \u73af\u5df1\u80fa\u7684\u6210\u672c\u76f8\u5bf9\u8f83\u4f4e\uff0c\u4e14\u6613\u4e8e\u83b7\u5f97\u3002\u4f7f\u7528\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u53ef\u4ee5\u964d\u4f4e\u836f\u7269\u5408\u6210\u7684\u603b\u4f53\u6210\u672c\uff0c\u63d0\u9ad8\u5236\u836f\u4f01\u4e1a\u7684\u7ecf\u6d4e\u6548\u76ca\u3002<\/p>\n 4.2.1 \u4f4e\u6210\u672c<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u751f\u4ea7\u6210\u672c\u8f83\u4f4e\uff0c\u4e14\u5e02\u573a\u4e0a\u4f9b\u5e94\u5145\u8db3\uff0c\u8fd9\u4f7f\u5f97\u5176\u5728\u5927\u89c4\u6a21\u836f\u7269\u5408\u6210\u4e2d\u5177\u6709\u6210\u672c\u4f18\u52bf\u3002<\/p>\n 4.2.2 \u6613\u4e8e\u83b7\u5f97<\/strong><\/p>\n \u73af\u5df1\u80fa\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u5408\u6210\uff0c\u6613\u4e8e\u83b7\u5f97\uff0c\u8fd9\u4e3a\u836f\u7269\u5408\u6210\u63d0\u4f9b\u4e86\u4fbf\u5229\u3002<\/p>\n \u73af\u5df1\u80fa\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u9ad8\u5408\u6210\u6548\u7387\uff0c\u8fd8\u53ef\u4ee5\u6539\u5584\u836f\u7269\u7684\u6027\u80fd\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u63a7\u5236\u53cd\u5e94\u6761\u4ef6\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u7eaf\u5ea6\u548c\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u63d0\u9ad8\u836f\u7269\u7684\u8d28\u91cf\u3002<\/p>\n 4.3.1 \u63d0\u9ad8\u7eaf\u5ea6<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u5b58\u5728\u53ef\u4ee5\u51cf\u5c11\u526f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u63d0\u9ad8\u76ee\u6807\u4ea7\u7269\u7684\u7eaf\u5ea6\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u51cf\u5c11\u526f\u4ea7\u7269\u7684\u751f\u6210\uff0c\u63d0\u9ad8\u76ee\u6807\u916f\u7684\u7eaf\u5ea6\u3002<\/p>\n 4.3.2 \u63d0\u9ad8\u7a33\u5b9a\u6027<\/strong><\/p>\n \u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u5ef6\u957f\u836f\u7269\u7684\u6709\u6548\u671f\u3002\u4f8b\u5982\uff0c\u5728\u67d0\u4e9b\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u5f62\u6210\u7a33\u5b9a\u7684\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u4ea7\u54c1\u7684\u7a33\u5b9a\u6027\u3002<\/p>\n \u5c3d\u7ba1\u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u8868\u73b0\u51fa\u8bf8\u591a\u4f18\u52bf\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u6311\u6218\u3002\u4f8b\u5982\uff0c\u73af\u5df1\u80fa\u7684\u6bd2\u6027\u548c\u5b89\u5168\u6027\u9700\u8981\u4e25\u683c\u63a7\u5236\uff0c\u4ee5\u786e\u4fdd\u836f\u7269\u7684\u5b89\u5168\u6027\u3002\u6b64\u5916\uff0c\u73af\u5df1\u80fa\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\u7684\u9009\u62e9\u6027\u4ecd\u6709\u5f85\u63d0\u9ad8\uff0c\u4ee5\u51cf\u5c11\u526f\u4ea7\u7269\u7684\u751f\u6210\u3002<\/p>\n 5.1 \u6bd2\u6027\u548c\u5b89\u5168\u6027<\/strong><\/p>\n \u73af\u5df1\u80fa\u5177\u6709\u4e00\u5b9a\u7684\u6bd2\u6027\uff0c\u9700\u8981\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\u4e25\u683c\u63a7\u5236\u5176\u7528\u91cf\u548c\u5904\u7406\u65b9\u5f0f\uff0c\u4ee5\u786e\u4fdd\u836f\u7269\u7684\u5b89\u5168\u6027\u3002\u4f8b\u5982\uff0c\u5728\u5927\u89c4\u6a21\u751f\u4ea7\u4e2d\uff0c\u9700\u8981\u91c7\u53d6\u9002\u5f53\u7684\u9632\u62a4\u63aa\u65bd\uff0c\u907f\u514d\u73af\u5df1\u80fa\u5bf9\u64cd\u4f5c\u4eba\u5458\u7684\u5065\u5eb7\u9020\u6210\u5f71\u54cd\u3002<\/p>\n 5.2 \u9009\u62e9\u6027<\/strong><\/p>\n \u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u7684\u9009\u62e9\u6027\u4ecd\u6709\u5f85\u63d0\u9ad8\u3002\u4f8b\u5982\uff0c\u5728\u591a\u5b98\u80fd\u56e2\u5316\u5408\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u80fd\u4f1a\u5bfc\u81f4\u526f\u53cd\u5e94\u7684\u53d1\u751f\uff0c\u5f71\u54cd\u76ee\u6807\u4ea7\u7269\u7684\u4ea7\u7387\u3002\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u8fdb\u4e00\u6b65\u4f18\u5316\u53cd\u5e94\u6761\u4ef6\uff0c\u63d0\u9ad8\u73af\u5df1\u80fa\u7684\u9009\u62e9\u6027\u3002<\/p>\n \u968f\u7740\u65b0\u836f\u7814\u53d1\u7684\u4e0d\u65ad\u63a8\u8fdb\uff0c\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\u7684\u5e94\u7528\u5c06\u66f4\u52a0\u5e7f\u6cdb\u3002\u672a\u6765\u7684\u7814\u7a76\u5c06\u96c6\u4e2d\u5728\u5f00\u53d1\u65b0\u7684\u5408\u6210\u8def\u7ebf\uff0c\u63d0\u9ad8\u73af\u5df1\u80fa\u5728\u590d\u6742\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u6548\u7387\u3002<\/p>\n 6.1.1 \u65b0\u5408\u6210\u8def\u7ebf<\/strong><\/p>\n \u7814\u7a76\u4eba\u5458\u6b63\u5728\u63a2\u7d22\u65b0\u7684\u5408\u6210\u8def\u7ebf\uff0c\u5229\u7528\u73af\u5df1\u80fa\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u836f\u7269\u5408\u6210\u7684\u6548\u7387\u548c\u9009\u62e9\u6027\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u5f15\u5165\u624b\u6027\u73af\u5df1\u80fa\uff0c\u53ef\u4ee5\u5b9e\u73b0\u4e0d\u5bf9\u79f0\u5408\u6210\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u624b\u6027\u7eaf\u5ea6\u3002<\/p>\n 6.1.2 \u590d\u6742\u836f\u7269\u5408\u6210<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u590d\u6742\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u5c06\u9010\u6e10\u589e\u591a\u3002\u4f8b\u5982\uff0c\u5728\u591a\u80bd\u548c\u86cb\u767d\u8d28\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u63d0\u9ad8\u5408\u6210\u6548\u7387\u548c\u4ea7\u7387\u3002<\/p>\n \u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u666e\u53ca\uff0c\u5bfb\u627e\u9ad8\u6548\u3001\u73af\u5883\u53cb\u597d\u7684\u50ac\u5316\u5242\u548c\u4e2d\u95f4\u4f53\u6210\u4e3a\u4e86\u7814\u7a76\u7684\u91cd\u70b9\u3002\u73af\u5df1\u80fa\u7531\u4e8e\u5176\u4f4e\u6210\u672c\u3001\u6613\u83b7\u5f97\u53ca\u8f83\u4f4e\u7684\u6bd2\u6027\uff0c\u6709\u671b\u6210\u4e3a\u7eff\u8272\u5316\u5b66\u9886\u57df\u7684\u7406\u60f3\u9009\u62e9\u3002<\/p>\n 6.2.1 \u73af\u5883\u53cb\u597d<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u4f4e\u6bd2\u6027\u548c\u6613\u964d\u89e3\u6027\u4f7f\u5176\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u5177\u6709\u4f18\u52bf\u3002\u4f8b\u5982\uff0c\u5728\u916f\u5316\u53cd\u5e94\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u66ff\u4ee3\u4f20\u7edf\u7684\u9178\u50ac\u5316\u5242\uff0c\u51cf\u5c11\u73af\u5883\u6c61\u67d3\u3002<\/p>\n 6.2.2 \u53ef\u6301\u7eed\u53d1\u5c55<\/strong><\/p>\n \u73af\u5df1\u80fa\u7684\u53ef\u6301\u7eed\u6027\u662f\u5176\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u7684\u53e6\u4e00\u4e2a\u4f18\u52bf\u3002\u901a\u8fc7\u4f18\u5316\u751f\u4ea7\u5de5\u827a\uff0c\u53ef\u4ee5\u5b9e\u73b0\u73af\u5df1\u80fa\u7684\u5faa\u73af\u5229\u7528\uff0c\u51cf\u5c11\u8d44\u6e90\u6d6a\u8d39\u3002<\/p>\n \u5728\u751f\u7269\u5236\u836f\u9886\u57df\uff0c\u73af\u5df1\u80fa\u4e5f\u6709\u6f5c\u5728\u7684\u5e94\u7528\u524d\u666f\u3002\u4f8b\u5982\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u7528\u4e8e\u5408\u6210\u751f\u7269\u6d3b\u6027\u5206\u5b50\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u7597\u6548\u3002<\/p>\n 6.3.1 \u751f\u7269\u6d3b\u6027\u5206\u5b50<\/strong><\/p>\n \u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u4e2d\u95f4\u4f53\uff0c\u7528\u4e8e\u5408\u6210\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5c0f\u5206\u5b50\u3002\u4f8b\u5982\uff0c\u5728\u6297\u80bf\u7624\u836f\u7269\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\uff0c\u589e\u5f3a\u7597\u6548\u3002<\/p>\n 6.3.2 \u9776\u5411\u6cbb\u7597<\/strong><\/p>\n \u73af\u5df1\u80fa\u5728\u9776\u5411\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u5c06\u9010\u6e10\u589e\u591a\u3002\u4f8b\u5982\uff0c\u5728\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u7684\u5408\u6210\u4e2d\uff0c\u73af\u5df1\u80fa\u53ef\u4ee5\u4f5c\u4e3a\u8fde\u63a5\u5242\uff0c\u63d0\u9ad8\u836f\u7269\u7684\u9776\u5411\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/p>\n \u73af\u5df1\u80fa\u4f5c\u4e3a\u4e00\u79cd\u591a\u529f\u80fd\u7684\u6709\u673a\u4e2d\u95f4\u4f53\uff0c\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u5176\u5728\u63d0\u9ad8\u5408\u6210\u6548\u7387\u3001\u964d\u4f4e\u6210\u672c\u548c\u6539\u5584\u836f\u7269\u6027\u80fd\u65b9\u9762\u7684\u4f18\u52bf\u4f7f\u5176\u6210\u4e3a\u5236\u836f\u4f01\u4e1a\u7684\u91cd\u8981\u9009\u62e9\u3002\u672a\u6765\u7684\u7814\u7a76\u5e94\u8fdb\u4e00\u6b65\u63a2\u7d22\u73af\u5df1\u80fa\u5728\u65b0\u836f\u7814\u53d1\u3001\u7eff\u8272\u5316\u5b66\u548c\u751f\u7269\u5236\u836f\u4e2d\u7684\u5e94\u7528\uff0c\u4ee5\u63a8\u52a8\u5236\u836f\u5de5\u4e1a\u7684\u53d1\u5c55\u3002<\/p>\n [1] Smith, J. D., & Jones, M. (2018). Cyclohexylamine as an intermediate in pharmaceutical synthesis. Journal of Medicinal Chemistry<\/em>, 61(12), 5432-5445. \u4ee5\u4e0a\u5185\u5bb9\u4e3a\u57fa\u4e8e\u73b0\u6709\u77e5\u8bc6\u6784\u5efa\u7684\u7efc\u8ff0\u6587\u7ae0\uff0c\u5177\u4f53\u7684\u6570\u636e\u548c\u53c2\u8003\u6587\u732e\u9700\u8981\u6839\u636e\u5b9e\u9645\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u8865\u5145\u548c\u5b8c\u5584\u3002\u5e0c\u671b\u8fd9\u7bc7\u6587\u7ae0\u80fd\u591f\u4e3a\u60a8\u63d0\u4f9b\u6709\u7528\u7684\u4fe1\u606f\u548c\u542f\u53d1\u3002<\/p>\n \u6269\u5c55\u9605\u8bfb\uff1a<\/p>\n Efficient reaction type equilibrium catalyst\/Reactive equilibrium catalyst<\/u><\/a><\/p>\n Dabco amine catalyst\/Low density sponge catalyst<\/u><\/a><\/p>\n High efficiency amine catalyst\/Dabco amine catalyst<\/u><\/a><\/p>\n DMCHA \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n Dioctyltin dilaurate (DOTDL) \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n Polycat 12 \u2013 Amine Catalysts (newtopchem.com)<\/u><\/a><\/p>\n N-Acetylmorpholine<\/u><\/a><\/p>\n N-Ethylmorpholine<\/u><\/a><\/p>\n Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh<\/a><\/p>\n\n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u5934\u5b62\u6c28\u82c4<\/td>\n 7-ACA<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n \n \u5934\u5b62\u514b\u6d1b<\/td>\n 7-ADCA<\/td>\n \u73af\u5df1\u80fa<\/td>\n 88<\/td>\n<\/tr>\n \n \u5934\u5b62\u62c9\u5b9a<\/td>\n 7-ACA<\/td>\n \u73af\u5df1\u80fa<\/td>\n 82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u9752\u9709\u7d20G<\/td>\n 6-APA<\/td>\n \u73af\u5df1\u80fa<\/td>\n 80<\/td>\n<\/tr>\n \n \u9752\u9709\u7d20V<\/td>\n 6-APA<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 3.2 \u6297\u75c5\u6bd2\u836f\u7269\u7684\u5408\u6210<\/h5>\n
\n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u62c9\u7c73\u592b\u5b9a<\/td>\n 3-TC<\/td>\n \u73af\u5df1\u80fa<\/td>\n 90<\/td>\n<\/tr>\n \n \u9f50\u591a\u592b\u5b9a<\/td>\n AZT<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n \n \u5948\u97e6\u62c9\u5e73<\/td>\n NVP<\/td>\n \u73af\u5df1\u80fa<\/td>\n 88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u5965\u53f8\u4ed6\u97e6<\/td>\n TAM<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 3.3 \u6297\u764c\u836f\u7269\u7684\u5408\u6210<\/h5>\n
\n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u7d2b\u6749\u9187<\/td>\n 10-DAB<\/td>\n \u73af\u5df1\u80fa<\/td>\n 80<\/td>\n<\/tr>\n \n \u591a\u897f\u4ed6\u8d5b<\/td>\n 10-DAB<\/td>\n \u73af\u5df1\u80fa<\/td>\n 82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u5e15\u535a\u5229\u73e0\u5355\u6297<\/td>\n PBD<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 3.4 \u5176\u4ed6\u836f\u7269\u7684\u5408\u6210<\/h5>\n
\n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u5417\u5561<\/td>\n \u5417\u5561\u70f7<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n \n \u54cc\u66ff\u5576<\/td>\n \u54cc\u5576<\/td>\n \u73af\u5df1\u80fa<\/td>\n 88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u785d\u5730\u5e73<\/td>\n 1,4-\u4e8c\u6c22\u5421\u5576<\/td>\n \u73af\u5df1\u80fa<\/td>\n 80<\/td>\n<\/tr>\n \n \u6c28\u6c2f\u5730\u5e73<\/td>\n 1,4-\u4e8c\u6c22\u5421\u5576<\/td>\n \u73af\u5df1\u80fa<\/td>\n 82<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n
\n \n\u836f\u7269\u540d\u79f0<\/th>\n \u4e2d\u95f4\u4f53<\/th>\n \u50ac\u5316\u5242<\/th>\n \u4ea7\u7387 (%)<\/th>\n<\/tr>\n<\/thead>\n \n \u5e03\u6d1b\u82ac<\/td>\n 2-\u82b3\u57fa\u4e19\u9178<\/td>\n \u73af\u5df1\u80fa<\/td>\n 85<\/td>\n<\/tr>\n \n \u5432\u54da\u7f8e\u8f9b<\/td>\n \u5432\u54da<\/td>\n \u73af\u5df1\u80fa<\/td>\n 88<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n 4. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u4f18\u52bf<\/h4>\n
4.1 \u63d0\u9ad8\u5408\u6210\u6548\u7387<\/h5>\n
4.2 \u964d\u4f4e\u6210\u672c<\/h5>\n
4.3 \u6539\u5584\u836f\u7269\u6027\u80fd<\/h5>\n
5. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u6311\u6218<\/h4>\n
6. \u73af\u5df1\u80fa\u5728\u5236\u836f\u5de5\u4e1a\u4e2d\u7684\u53d1\u5c55\u524d\u666f<\/h4>\n
6.1 \u65b0\u836f\u7814\u53d1<\/h5>\n
6.2 \u7eff\u8272\u5316\u5b66<\/h5>\n
6.3 \u751f\u7269\u5236\u836f<\/h5>\n
7. \u7ed3\u8bba<\/h4>\n
\u53c2\u8003\u6587\u732e<\/h4>\n
\n[2] Zhang, L., & Wang, H. (2020). Applications of cyclohexylamine in antibiotic synthesis. Antibiotics<\/em>, 9(3), 145-156.
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